What if docs might information life-saving therapies by means of the physique utilizing nothing however a magnet?
An interdisciplinary workforce on the College of Pittsburgh’s Swanson Faculty of Engineering is working to make that concept a actuality. They’ve developed silk iron microparticles (SIMPs)—tiny, magnetic, biodegradable carriers designed to ship medicine and coverings on to particular websites within the physique, corresponding to aneurysms or tumors.
The hassle is led by Pitt alumna Ande Marini (BioE PhD ‘25), now a postdoctoral scholar in cardiothoracic surgical procedure at Stanford College, alongside David Vorp, John A. Swanson Professor of Bioengineering, and Justin Weinbaum, analysis assistant professor of bioengineering.
Their findings, titled “Chemical Conjugation of Iron Oxide Nanoparticles for the Growth of Magnetically Directable Silk Particles” (DOI: 10.1021/acsami.4c17536), had been revealed within the February version of ACS Utilized Supplies & Interfaces.
Marini and her colleagues had been motivated by their lab’s ongoing work to enhance remedy choices for stomach aortic aneurysms (AAA), a situation that may be deadly if left untreated and contributes to almost 10,000 deaths yearly.
Their strategy focuses on noninvasive, early-stage supply of regenerative therapies utilizing extracellular vesicles—small, membrane-bound capsules that assist cells talk.
We need to discover a option to ship extracellular vesicles to the positioning of an stomach aortic aneurysm within the least invasive approach doable. We envisioned that we might inject extracellular vesicles onto a provider after which in some way information the provider to the skin of the aortic wall, so we got here up with the thought of utilizing magnetic attraction.
David A. Vorp, Division of Bioengineering, College of Pittsburgh
To deliver that concept to life, the workforce partnered with Mostafa Bedewy, affiliate professor of mechanical engineering and supplies science on the Swanson Faculty, and his former Ph.D. scholar, Golnaz Tomaraei (IE PhD ‘23).
Their experience in nanomaterials and fabrication was important in producing the magnetic nanoparticles, every simply one-hundred-thousandth the width of a human hair. At that scale, supplies behave in another way, taking over properties like magnetic responsiveness.
Our function was to synthesize magnetic nanoparticles with the best properties and bond them to the silk so they might keep hooked up throughout motion. You’ll be able to consider it like towing cargo we created the particles to hold medicine, and the nanoparticles are the tow hook.
Mostafa Bedewy, Division of Mechanical Engineering and Supplies Science, College of Pittsburgh
Whereas magnetically guideable supplies have been utilized in medical purposes earlier than, what units this work aside is the chemical bonding of the magnetic particles to silk—a biocompatible materials already permitted by the FDA—utilizing the compound glutathione.
We bridged biomaterials and chemical conjugation to create particles that might be magnetically guided. By chemically bonding iron oxide nanoparticles to the regenerated silk fibroin, we enhanced their magnetic movability so we will probably localize them externally to a website of curiosity within the physique.
Ande X. Marini, Division of Bioengineering, College of Pittsburgh
This breakthrough opens up a spread of future potentialities, from focused most cancers therapies to regenerative therapies for heart problems. The speedy subsequent step can be loading these carriers with therapeutic brokers.
Marini stated, “With this paper, we’re displaying that we will create an empty provider that may be magnetically moved. The subsequent step is determining what sort of cargo we will load, regenerative elements, medicine, or different supplies folks need to magnetically localize. Whether or not it’s delivering most cancers medicine with fewer negative effects or slowing down tissue degradation in aneurysms, this expertise has broad potential for regenerative drugs.”
For Bedewy’s workforce, this additionally means persevering with to refine the molecular construction of the particles and optimizing how they launch their cargo over time.
Bedewy stated, “We are attempting to create a toolbox of therapies, and in supplies science, there may be a whole lot of room for making extra instruments that may be helpful for medical docs and bioengineers to assist create other ways of resolving issues within the physique. That is an thrilling venture the place folks with very totally different units of experience got here collectively to resolve an issue and produce an consequence that would probably have an immense impression on human lives.”
Journal Reference:
Marini, A. X., et al. (2025) Chemical Conjugation of Iron Oxide Nanoparticles for the Growth of Magnetically Directable Silk Particles. ACS Utilized Supplies & Interfaces. doi.org/10.1021/acsami.4c17536.
