Medical-grade extracellular vesicles derived from umbilical wire mesenchymal stromal cells: preclinical growth and first-in-human intra-articular validation as therapeutics for knee osteoarthritis | Journal of Nanobiotechnology

Medical-grade extracellular vesicles derived from umbilical wire mesenchymal stromal cells: preclinical growth and first-in-human intra-articular validation as therapeutics for knee osteoarthritis | Journal of Nanobiotechnology

Non-clinical (non cGMP) sEV manufacturing and enrichment Preclinical sEV batches had been obtained as reported beforehand [20]. Briefly, UC-MSC from three donors in passage 5 had been seeded and expanded in a upkeep medium composed of Dulbecco’s modified Eagle’s medium (DMEM), excessive glucose, supplemented with 1% penicillin/streptomycin resolution (10,000 U/mL and 10,000 μg/mL, respectively), 1% L-glutamine (200 mM)…

Read More
Autophagosomes coated in situ with nanodots act as customized most cancers vaccines

Autophagosomes coated in situ with nanodots act as customized most cancers vaccines

Kaiser, J. Personalised tumour vaccines preserve most cancers in examine. Science 356, 122 (2017). Article  PubMed  CAS  Google Scholar  Pulendran, B. & Davis, M. M. The science and medication of human immunology. Science 369, eaay4014 (2020). Article  PubMed  PubMed Central  CAS  Google Scholar  Ci, T. et al. Cryo-shocked most cancers cells for focused drug supply…

Read More
Sustainable ZnO Nanoparticles for Methylene Blue Cleanup

Sustainable ZnO Nanoparticles for Methylene Blue Cleanup

In a latest article printed in Scientific Experiences, researchers explored the inexperienced synthesis of zinc oxide nanoparticles (ZnO NPs) utilizing the extract of Padina pavonica, a brown algae. They evaluated their effectiveness in eradicating methylene blue dye from aqueous options. The analysis goals to display the potential of those biogenic nanoparticles as a viable resolution…

Read More
Covalent natural frameworks reveal appreciable potential for environment friendly vitality transport

Covalent natural frameworks reveal appreciable potential for environment friendly vitality transport

Laura Spies appears to be like at one of many COF skinny movies examined within the examine. Credit score: Florian Wolf An interdisciplinary analysis group from LMU, the Technical College of Munich (TUM), and the College of Oxford has employed novel spectroscopic methods to research the diffusion of excited states in covalent natural frameworks (COFs)….

Read More
Harnessing corrosion: Scientists rework dealloying into sustainable light-weight alloy design

Harnessing corrosion: Scientists rework dealloying into sustainable light-weight alloy design

Alloying, the artwork of mixing metals with different components, has lengthy been a cornerstone of supplies science and metallurgy, creating supplies with tailor-made properties. In distinction, dealloying has been identified primarily as a corrosive course of that degrades supplies over time by selectively eradicating components, weakening their construction. Now, researchers on the Max Planck Institute…

Read More
Silk-engineered bioactive nanoparticles for focused alleviation of acute inflammatory illness through macrophage reprogramming | Journal of Nanobiotechnology

Silk-engineered bioactive nanoparticles for focused alleviation of acute inflammatory illness through macrophage reprogramming | Journal of Nanobiotechnology

Synthesis and characterization of bioactive TPSF materials with ROS-scavenging potential Tpl is a SOD-mimetic agent that may successfully neutralize superoxide anions and oxygen radicals [65]. In the meantime the PBAP unit is ready to stoichiometrically inactivate H2O2 [41]. Thus, we designed a silk-based ROS scavenger, outlined as TPSF, which was concurrently chemically modified with each…

Read More
Ferrimagnetic Heusler tunnel junctions with quick spin-transfer torque switching enabled by low magnetization

Ferrimagnetic Heusler tunnel junctions with quick spin-transfer torque switching enabled by low magnetization

Launch, S. P. Samsung reveals eMRAM and BCD roadmap whereas pushing automotive chip all the way down to 2 nm. https://www.digitimes.com/information/a20231020PD215/automotive-ic-ev-memory-chips-samsung.html (2023). Parkin, S. S. P. et al. Large tunnelling magnetoresistance at room temperature with MgO (100) tunnel limitations. Nat. Mater. 3, 862 (2004). Article  CAS  PubMed  Google Scholar  Yuasa, S., Nagahama, T., Fukushima, A.,…

Read More
A Recreation Changer for Nanoscale Electronics

A Recreation Changer for Nanoscale Electronics

Reviewed by Lexie NookJan 9 2025 A latest research revealed in Science by researchers at Stanford College demonstrated that niobium phosphide movies, only some atoms thick, can conduct electrical energy extra effectively than copper. A movie a number of atoms thick of non-crystalline niobium phosphide conducts higher via the floor to make the fabric, as an…

Read More
Janus graphene nanoribbons poised to advance quantum applied sciences

Janus graphene nanoribbons poised to advance quantum applied sciences

An atomic mannequin of the Janus graphene nanoribbons (left) and its atomic pressure microscopic picture (proper). Credit score: Nationwide College of Singapore Researchers from the Nationwide College of Singapore (NUS) have just lately achieved a big breakthrough within the growth of next-generation carbon-based quantum supplies, opening new horizons for developments in quantum electronics. The innovation…

Read More