![Built-in triple sign amplification technique for ultrasensitive electrochemical detection of gastric cancer-related microRNA using MoS2-based nanozyme, hybridization chain response, and horseradish peroxidase | Journal of Nanobiotechnology Built-in triple sign amplification technique for ultrasensitive electrochemical detection of gastric cancer-related microRNA using MoS2-based nanozyme, hybridization chain response, and horseradish peroxidase | Journal of Nanobiotechnology](https://i1.wp.com/static-content.springer.com/image/art%3A10.1186%2Fs12951-024-02848-z/MediaObjects/12951_2024_2848_Fig2_HTML.png?w=600&resize=600,400&ssl=1)
Built-in triple sign amplification technique for ultrasensitive electrochemical detection of gastric cancer-related microRNA using MoS2-based nanozyme, hybridization chain response, and horseradish peroxidase | Journal of Nanobiotechnology
Design precept of the electrochemical biosensor As illustrated in Scheme 1, P1 was firstly assembled on electrode floor by way of Au-S bond. After passivating the electrode floor with MCH, goal miR-19b-3p and P2-HCR-I/MoS2-Au@Pt nanoprobes had been launched to assemble P2-HCR-I/MoS2-Au@Pt/miR-19b-3p/P1/Au because of the formation of P1-miR-19b-3p-P2 sandwiched construction. Then, the assembled HCR-I triggered the…