In a current article revealed in Scientific Studies, researchers introduced a composite wound dressing composed of polylactic acid (PLA), curcumin, and carbon nanotubes (CNTs), designed to enhance mechanical energy and antibacterial exercise.
The dressing was fabricated utilizing electrospinning, with CNTs included to boost curcumin launch and maintain antibacterial effectiveness via nanoscale structural management.
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Background
Wound therapeutic is a posh physiological course of that may be compromised by an infection and impaired tissue regeneration. Standard dressings, usually created from pure fibers reminiscent of cotton or linen, provide restricted performance. Nanofiber scaffolds, significantly these based mostly on biocompatible polymers like PLA, present excessive floor space and porosity, making them appropriate for managed drug supply and tissue interplay.
Curcumin, a bioactive compound derived from turmeric, has demonstrated anti-inflammatory and antibacterial properties. Nonetheless, its use in wound care is proscribed by poor solubility and low bioavailability. CNTs provide complementary benefits: they possess intrinsic antibacterial exercise and might enhance the mechanical properties and drug launch profiles of polymer-based programs.
This examine investigates the combination of CNTs into PLA-curcumin nanofibers to create a multifunctional wound dressing able to each structural assist and an infection management.
The Present Examine
The dressing was produced utilizing electrospinning, a way appropriate for fabricating nanofibers with managed morphology. PLA (molecular weight: 203,000 g/mol) was dissolved in dichloromethane, adopted by the addition of curcumin to make sure uniform dispersion. CNTs have been included at various concentrations to evaluate their results on the fabric’s structural and practical properties.
Electrospun nanofibers have been collected utilizing a normal setup with a managed stream charge and glued needle-to-collector distance. Characterization included Fourier-transform infrared spectroscopy (FTIR) for chemical evaluation and scanning electron microscopy (SEM) for morphology. Tensile checks evaluated mechanical energy, whereas curcumin launch profiles have been analyzed via in vitro assays. Antibacterial efficiency was assessed utilizing normal strains of Staphylococcus aureus and Escherichia coli.
Outcomes and Dialogue
Incorporating CNTs considerably improved the mechanical energy and thermal stability of the PLA-curcumin nanofibers. Tensile testing confirmed that even small additions of CNTs enhanced tensile energy in comparison with pure PLA. Drug launch research confirmed a managed and sustained launch of curcumin, with the speed modulated by CNT focus. This impact was attributed to adjustments in scaffold porosity and microstructure.
Antibacterial assays revealed that CNT-containing composites had a marked inhibitory impact on bacterial development. The PLA-Cur-0.05 % CNT formulation confirmed the very best antibacterial exercise, with a 78.95 % discount in microbial development. Whereas curcumin alone confirmed restricted antibacterial efficacy within the PLA matrix, CNTs appeared to assist each dispersion and membrane-disruptive mechanisms, contributing to improved outcomes.
Water absorption checks additional supported the composite’s suitability for wound care. Whereas PLA alone exhibited excessive water uptake, the addition of curcumin and CNTs decreased this absorption. A extra average water uptake profile is advantageous for managing exudates with out compromising the mechanical integrity of the dressing.
Conclusion
This examine demonstrates the potential of CNT-enhanced PLA-curcumin nanofiber mats as multifunctional wound dressings. The mix of improved mechanical properties, antibacterial exercise, and managed drug launch gives a promising platform for an infection administration and wound therapeutic assist. The design leverages nanostructure engineering to beat the constraints of typical supplies and drug supply programs.
Future analysis ought to discover in vivo efficiency, scalability, and additional refinement of the composite formulation. Optimizing element ratios and evaluating long-term biocompatibility will likely be key steps towards medical software.
Journal Reference
Faal M., et al. (2025). Fabrication and analysis of polylactic acid-curcumin containing carbon nanotubes (CNTs) wound dressing utilizing electrospinning technique with experimental and computational approaches. Scientific Studies. DOI: 10.1038/s41598-025-98393-2, https://www.nature.com/articles/s41598-025-98393-2
